Behavioral experiments with rat models of depression featuring both implantable focused ultrasound neurostimulation and electrical recording devices, ideally require light and compact electronics that can simultaneously control the implantable devices and relay information to and from a computer for the proper control of the experiments and data analysis. We have

The UPSIDE project has the overall goal of combining electrical recording and ultrasound stimulation for the treatment of depression, as a less invasive alternative to the more intrusive approach of deep brain stimulation. The overall system is designed to be portable, with the core consisting of an epidural focused ultrasound

Clinical depression is associated with dysfunctional neural networks that regulate mood, emotion and reward-orientated behaviours. Neuromodulation is a therapeutic strategy aiming to correct the activity of the pathological pathways that underpin the key symptoms. The current project aims to produce an implantable epidural brain interface (EBI) with low-intensity focused ultrasound

This work aims to provide stakeholders with an accessible overview of the project’s technological strides, and the implications of these developments for future research and applications. The primary objective of WP2 in UPSIDE is to enhance the resolution and efficacy of neurophysiological data acquisition. Traditional methods face challenges in spatial

UPSIDE explores the potential of non-invasive electroencephalography (EEG) as a neuroimaging technique to detect biomarkers for Major Depressive Disorder (MDD). EEG, measuring brain electrical activity through scalp electrodes, has gained attention for its ability to reveal patterns associated with depression. Abnormalities in alpha wave activity, alpha/beta ratio, frontal asymmetry, and